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M94A0256.TXT
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1994-10-08
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Document 0256
DOCN M94A0256
TI Deficiency in antibody response to human cytomegalovirus glycoprotein gH
in human immunodeficiency virus-infected patients at risk for
cytomegalovirus retinitis.
DT 9412
AU Rasmussen L; Morris S; Wolitz R; Dowling A; Fessell J; Holodniy M;
Merigan TC; Stanford University School of Medicine, Center for AIDS
Research; and Division of Infectious Diseases and Geographic Medicine,;
California 94305.
SO J Infect Dis. 1994 Sep;170(3):673-7. Unique Identifier : AIDSLINE
MED/94358505
AB Human immunodeficiency virus (HIV)-infected patients at risk for
symptomatic human cytomegalovirus (CMV) infection were studied for serum
antibody to CMV glycoproteins gH and gB. Antibody titers to gB in
HIV-seropositive patients, irrespective of CD4 cell counts or presence
of CMV retinitis, were significantly higher than titers in
HIV-seronegative, CMV-seropositive patients but were comparable to
titers detected in HIV-seronegative patients with CMV mononucleosis. In
contrast, antibody to gH was rarely detected in HIV-seropositive
patients with CD4 cell counts > 100/mm3 compared with patients with
counts > 100/mm3. The inability to detect gH antibody at a time of high
risk for symptomatic CMV retinitis suggests that immune intervention
with either gH-specific vaccine or passive immunotherapy may benefit
HIV-infected persons at risk for symptomatic CMV disease.
DE Antibodies, Viral/*BLOOD *Antibody Formation AIDS-Related
Opportunistic Infections/*EPIDEMIOLOGY Comparative Study
Cytomegalovirus/*IMMUNOLOGY Cytomegalovirus Retinitis/*EPIDEMIOLOGY
Enzyme-Linked Immunosorbent Assay Human *HIV Seronegativity HIV
Seropositivity/BLOOD/*MICROBIOLOGY IgG/*BLOOD Leukocyte Count
Reference Values Risk Factors Support, Non-U.S. Gov't Support, U.S.
Gov't, P.H.S. T4 Lymphocytes/IMMUNOLOGY Viral Envelope
Proteins/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).